NATIONAL
CALIFORNIA
VENTURA
mechanism
- Blocks acetylcholine from binding to receptors on motor endplate inhibiting depolarization
indications
- Neuromuscular blockade for endotracheal intubation and mechanical ventilation
contraindications
- Hypersensitivity (eg, anaphylaxis) to rocuronium, other neuromuscular-blocking agents, or any component of the formulation
dosing
Adult
IV: 1.2 to 1.5 mg/kg; administration of 1.5 mg/kg may provide optimal conditions for tracheal intubation
Pediatric
IV: Usual: 1 mg/kg; range: 0.6 to 1.2 mg/kg
administration
IV: Administer undiluted by rapid IV injection.
onset
Infants ≥ 3 months and Children: 30 seconds to 1 minute.
Adults: Good intubation conditions within 1 to 3 minutes; maximum neuromuscular blockade within 4 minutes.
duration
Infants: 3 to 12 months: 40 minutes
Children: 1 to 12 years: 26 to 30 minutes
Adults: ~20 to 70 minutes (dose dependent, increases with higher doses and inhalational anesthetic agents); hypothermia may prolong the duration of action
notes
- Experienced personnel: Should be administered by adequately trained individuals familiar with its use.
dosage form
Solution, Intravenous: 50 mg/5 mL (5 mL); 100 mg/10 mL (10 mL)
brand name
Zemuron
adverse reactions
- Cardiovascular
- Increased peripheral vascular resistance, tachycardia, hypertension, transient hypotension
- Hypersensitivity
- Anaphylaxis
structure
