NATIONAL
CALIFORNIA
VENTURA
mechanism
  • Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors (lipid hormones which have a wide range of effects throughout the body); has antipyretic, analgesic, and anti-inflammatory properties
indications
  • Oral: Management of inflammatory diseases and rheumatoid disorders, mild to moderate pain, fever, dysmenorrhea, and osteoarthritis
contraindications
  • History of asthma, urticaria, or allergic-type reaction to aspirin or other NSAIDs
  • Cerebrovascular bleeding or other bleeding disorders
  • Active gastric/duodenal/peptic ulcer, active GI bleeding
  • Inflammatory bowel disease
  • Uncontrolled heart failure
dosing

Adult:

Oral: 600 to 800 mg every 6 to 8 hours as needed; maximum dose: 3.2 g/day

Pediatric:

Oral: 10 mg/kg/dose every 6 to 8 hours; maximum dose: 600 mg/dose; maximum daily dose: 2.4 g/day

administration
Oral: Administer with food or milk.
onset

30 to 60 minutes

peak

2 to 4 hours

duration

6 to 8 hours

notes
  • Side effects: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic and gastrointestinal events.
dosage form
Oral capsule and tablet: 100mg, 200 mg, 400 mg, 600 mg, 800 mg
Oral suspension: 100 mg/5 mL
brand name
Advil
Motrin
adverse reactions
  • Cardiovascular
    • Increased risk of serious adverse cardiovascular events, including acute myocardial infarction (MI) and cerebrovascular accident
    • Hypertension
    • Heart failure
  • Gastrointestinal
    • GI inflammation
    • GI hemorrhage
    • GI ulcer
    • GI perforation
  • Hematologic
    • Prolonged bleeding time
    • Hemorrhage
    • Hemolytic anemia
    • Thrombocytopenia (low platelets)
  • Hypersensitivity reactions
    • Angioedema
    • Urticaria
    • Stevens-Johnson syndrome (rare serious disorder of the skin and mucous membranes)
  • Kidney
    • Acute kidney injury
structure
ibuprofen.svg molecular structure