NATIONAL
CALIFORNIA
VENTURA
category
mechanism
- Displaces plasminogen (an enzyme that breaks down clots) from fibrin (a protein that forms the structure of clots)
- Inhibits the activity of plasmin (an enzyme that breaks down clots)
indications
- Trauma-associated hemorrhage or traumatic brain injury
contraindications
- Active intravascular clotting
- Subarachnoid hemorrhage: cerebral edema and infarction may occur
dosing
Adult
IV: 1 g over 10 minutes started within 3 hours of injury
Pediatric
Children < 12 years
IV: 15 mg/kg over 10 minutes given within 3 hours of injury, maximum 1 g
Children ≥ 12 years
Follow adult dosing
administration
Administer by IV injection at a maximum rate of 100 mg/minute; faster rates may cause hypotension.
onset
10 minutes
duration
3 hours
notes
- Infusion rate: Rapid infusion may cause hypotension
dosage form
IV solution: 1000 mg/10 mL (10 mL)
adverse reactions
- Hypersensitivity reactions
- Anaphylaxis
- Pruritus
- Urticaria
- Angioedema, wheezing, hypotension
- Anaphylactic shock
- Ocular effects
- Vision color changes
- Visual impairment
- Vision loss
- Retinal artery occlusion
- Retinal venous occlusion
- Conjunctivitis
- Seizures and myoclonus
- Myoclonus in ~20% of patients
- Seizures
- Thromboembolic events
- Deep vein thrombosis
- Pulmonary embolism
- Gastrointestinal
- Abdominal pain
- Nervous system
- Headache
- Dizziness
- Neuromuscular & skeletal
- Back pain
- Musculoskeletal pain
structure
