NATIONAL
CALIFORNIA
VENTURA
category
mechanism
- Binds to opioid receptors in the CNS, causing inhibition of pain pathways, altering the perception of and response to pain; produces generalized CNS depression
indications
- Pain management
contraindications
- Significant respiratory depression
- Acute or severe bronchial asthma
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or use of MAOIs within the last 14 days
dosing
Adult
IV, SubQ: 1 to 4 mg every 1 to 4 hours as needed; may increase dose as tolerated up to 10 mg every 4 hours
Pediatric
Weight <50 kg
IV, SubQ: 0.1 mg/kg/dose every 2 to 4 hours, maximum dose: 4 mg
Weight ≥50 kg
follow adult dosing
administration
Administer via slow IV push over 4 to 5 minutes (rapid administration may result in chest wall rigidity)
onset
5 to 10 minutes
duration
3 to 5 hours
notes
- Reversal: Opiate antagonist drugs (naloxone) oxygen and resuscitation equipment should be readily available during the administration of fentanyl
- CNS depression: additive CNS depression may occur if used with other CNS depressants
dosage form
Injection solution: 0.5 mg/mL (10 mL); 1 mg/mL (10 mL); 2 mg/mL (1 mL); 4 mg/mL (1 mL); 5 mg/mL (1 mL); 8 mg/mL (1 mL); 10 mg/mL (1 mL)
adverse reactions
- Respiratory
- Apnea
- Hypoventilation
- Laryngospasm
- Cardiovascular
- Arrhythmia
- Hypertension
- Hypotension
- Peripheral edema
- Nervous system
- Confusion
- Dizziness
- Drowsiness
- Gastrointestinal
- Abdominal pain
- Anorexia
- Constipation
- Diarrhea
- Nausea
- Vomiting
structure
