NATIONAL
CALIFORNIA
VENTURA
mechanism
  • Blocks the action of acetylcholine at parasympathetic sites in bronchial smooth muscle causing bronchodilation
indications
  • Asthma and Chronic Obstructive Pulmonary Disease: Treatment of bronchospasm
contraindications
  • Allergies: Soy/peanut allergy is NOT a contraindication with current preparations
dosing

Adult

Nebulized: 0.5 mg

Inhaler: 4-8 inhalations (68-136 mcg)

Pediatric:

Nebulized: 0.25 mg

Inhaler: 4 inhalations (68 mcg)

administration
Nebulizer: adjust nebulizer flow to deliver dosage over 5 to 15 minutes; use a mask device if patient unable to hold mouthpiece in mouth for administration. Compatible with albuterol in nebulizer.
Inhalers: Prime prior to first use, and whenever inhaler has not been used for >3 days by releasing 2 test sprays into the air. Does not require shaking.
onset

15 minutes

peak

1 to 2 hours

duration

Inhaler: 2 to 4 hours
Nebulization solution: 4 to 5 hours

notes
  • Administration with albuterol: Can be administered with albuterol in nebulizer
  • Allergy:There is no increased risk of allergic reaction with soy/peanut allergy. Older prepartions contained soy lecithin but current formulations do not.
dosage form
Nebulization Solution: 0.02% (2.5 mL)
Inhalation: 17 mcg/actuation
brand name
Atrovent
adverse reactions
  • Cardiovascular
    • Angina
    • Arrhythmias
    • Hypertension
    • Palpitations
  • Gastrointestinal
    • Nausea/Vomiting
  • Central Nervous System
    • Nervousness
    • Restlessness
    • Tremors
    • Headache
    • Insomnia
structure
ipratropium.svg molecular structure