NATIONAL
CALIFORNIA
VENTURA
category
mechanism
- Potentiates the action of antithrombin III, a protein in the blood that blocks blood clots from forming. This inactivates thrombin (an enzyme in blood plasma which causes the clotting) as well as other coagulation factors.
indications
- Ischemic heart disease: STEMI and NSTEMI - Can be used as an adjunct to percutaneous coronary intervention (stenting) or fibrinolysis
contraindications
- Severe thrombocytopenia
- History of heparin-induced thrombocytopenia
- Uncontrolled active bleeding
dosing
IV: Bolus 60 units/kg (maximum: 4,000 units), followed by 12 units/kg/hour (maximum: 1,000 units/hour)
administration
Continuous IV infusion: Infuse via infusion pump
onset
Immediate
duration
1 to 2 hours
notes
- Indications: Heparin may be given by continuous IV infusion or SUBQ for several different indications: DVT/PE treatment, prophylaxis for patients with atrial fibrillation, peripheral arterial occlusion, preventing clotting in dialysis and central venous catheters.
dosage form
Many concentrations of heparin are available ranging from 1 to 20,000 units/mL. Carefully examine each prefilled syringe or vial to ensure the correct concentration is selected.
adverse reactions
- Hematologic
- Bruising
- Hemorrhage
- Thrombocytopenia
- Hemorrhagic stroke
structure
