NATIONAL
CALIFORNIA
VENTURA
category
mechanism
- Haloperidol is an antipsychotic that blocks dopamine D2 receptors in the brain
indications
- Treatment of severe agitation/aggression associated with psychiatric disorders (eg, schizophrenia), substance intoxication, or other causes.
contraindications
- Parkinson disease
- Severe CNS depression
- Coma
- Dementia
dosing
IV, IM: 2 to 10 mg; repeat dose every ≥ 15 minutes until acute symptoms are controlled
administration
May be administered IM or IV
onset
15 minutes
duration
2-4 hours
notes
- QT prolongation: IV administration has been associated with QT prolongation and the manufacturer recommends ECG monitoring for QT prolongation and arrhythmias
dosage form
Injection solution: 5 mg/mL (1 mL)
brand name
Haldol
adverse reactions
- Extrapyramidal Symptoms
- Acute dystonia (involuntary muscle contractions that cause slow repetitive movements or abnormal postures)
- Drug-induced parkinsonism (rigidity, tremors, and slowness of movement)
- Akathisia (inability to remain still)
- Tardive dyskinesia (causes repetitive, involuntary facial movements, such as grimacing and eye blinking)
- Hematologic abnormalities
- Leukopenia (low white blood cells)
- Neutropenia (now neutrophil blood cells)
- Thrombocytopenia (low platelets)
- Hyperprolactinemia
- Higher-than-normal levels of prolactin in your blood causing infertility, decreased sex drive, and bone loss in both sexes
- Neuroleptic malignant syndrome
- Life-threatening neurological disorder. Symptoms include: high fever, sweating, irregular or fast heartbeat, high or low blood pressure.
- QTc prolongation
- Haloperidol has been associated with a prolonged QT interval on ECG, torsades de pointes
structure
