NATIONAL
CALIFORNIA
VENTURA
mechanism
  • Stimulates alpha, beta-1, and beta-2 adrenergic receptors resulting in relaxation of smooth muscle of the bronchial tree and cardiac stimulation (increasing myocardial oxygen consumption)
  • Constricts vascular smooth muscle
indications
  • Anaphylaxis
  • Severe Asthma
contraindications
  • No absolute contraindications
dosing

Adult

Anaphylaxis, Asthma

IM: 0.3 mg every 5 to 15 minutes

Pediatric

Anaphylaxis, Asthma

IM: 0.01 mg/kg/dose not to exceed: Prepubertal child: 0.3 mg/dose; adolescent: 0.3 mg every 5 to 15 minutes

administration
IM
onset

rapid

duration

<5 minutes

notes
  • Cardiovascular disease: Increases cardiac workload and myocardial oxygen demand - use with extreme caution in patients with myocardial ischemia, cardiomyopathy or cardiogenic shock.
  • Older adults: Use with caution in older adults.
dosage form
1 mg/mL (10 mL) (1:1,000)
brand name
EpiPen
adverse reactions
  • Cardiovascular
    • Angina, Arrhythmias (V-fib, V-tach), Hypertension, Palpitations, Tachycardia
  • Gastrointestinal
    • Nausea/Vomiting
  • CNS
    • Nervousness, Restlessness, Tremors, Headache
structure
epinephrine.svg molecular structure