NATIONAL
CALIFORNIA
VENTURA
category
mechanism
- Stimulates alpha, beta-1, and beta-2 adrenergic receptors resulting in relaxation of smooth muscle of the bronchial tree and cardiac stimulation (increasing myocardial oxygen consumption)
- Constricts vascular smooth muscle
indications
- Anaphylaxis
- Severe Asthma
contraindications
- No absolute contraindications
dosing
Adult
Anaphylaxis, Asthma
IM: 0.3 mg every 5 to 15 minutes
Pediatric
Anaphylaxis, Asthma
IM: 0.01 mg/kg/dose not to exceed: Prepubertal child: 0.3 mg/dose; adolescent: 0.3 mg every 5 to 15 minutes
administration
IM
onset
rapid
duration
<5 minutes
notes
- Cardiovascular disease: Increases cardiac workload and myocardial oxygen demand - use with extreme caution in patients with myocardial ischemia, cardiomyopathy or cardiogenic shock.
- Older adults: Use with caution in older adults.
dosage form
1 mg/mL (10 mL) (1:1,000)
brand name
EpiPen
adverse reactions
- Cardiovascular
- Angina, Arrhythmias (V-fib, V-tach), Hypertension, Palpitations, Tachycardia
- Gastrointestinal
- Nausea/Vomiting
- CNS
- Nervousness, Restlessness, Tremors, Headache
structure