NATIONAL
CALIFORNIA
VENTURA
category
mechanism
- Stimulates both adrenergic and dopaminergic receptors, lower doses are mainly dopaminergic stimulating and produce renal and mesenteric vasodilation, higher doses also are both dopaminergic and beta-1 stimulating and produce cardiac stimulation and renal vasodilation; large doses stimulate alpha receptors
indications
- Hypotension or shock: Treatment of severe hypotension or shock that persists during and after adequate fluid volume replacement.
contraindications
- Hypersensitivity to sulfites
- Pheochromocytoma
- Uncorrected tachyarrhythmias
- Ventricular fibrillation
dosing
IV: 5 to 15 mcg/kg/minute
administration
IV Continuous Infusion
onset
5 minutes
duration
<10 minutes
notes
- Appropriate use: Hypovolemia should be corrected before giving dopamine
- Sodium Bicarbonate: Dopamine may be inactivated by alkaline solutions such as sodium bicarbonate
- Monoamine oxidase inhibitors (MAO-I): Use with extreme caution in patients taking MAO inhibitors; prolong hypertension may result from concurrent use
dosage form
40 mg/mL (5 mL, 10 mL)
brand name
Intropin
adverse reactions
- Cardiovascular
- Arrhythmias, hypertension, hypotension, palpitations
- Gastrointestinal
- Nausea, vomiting
- Nervous system
- Anxiety, headache
- Respiratory
- Dyspnea
structure
