Pregnancy Classes

• VC 705.09 Chest Pain – Acute Coronary Syndrome
• SB 533-11 Chest Pain – Acute Coronary Syndrome
• LA County Ref. No. 1211 Cardiac Chest Pain

• Inhibits prostaglandin synthesis by irreversibly inhibiting cyclooxygenase (COX-1) lasting the life of the platelet

• Adult patients experiencing chest pain suggestive of acute coronary syndrome

• Patients with bleeding disorders (e.g. hemophilia, low platelets)

Oral: 324/325 mg (4 x 81mg = 324 mg)

Chewing tablets results in inhibition of platelet aggregation within 20 minutes

Chewing enteric-coated tablets results in a time to peak concentration of 2 hours

Platelet inhibitory effects last the lifetime of the platelet (~10 days) due to its irreversible inhibition of platelet COX-1

• Administration: The patient should chew the tablets prior to swallowing
• Bleeding risk: Aspirin will increase the risk of bleeding when combined with anticoagulants and thrombolytic therapy.
• Pediatrics: Aspirin should not be given to children or adolescents with viral infections due to the risk of developing Reye's syndrome.
• Hypersensitivity: Patients who have asthma, allergies, and nasal polyps or who are allergic to tartrazine are at an increased risk for developing hypersensitivity reactions.

• Respiratory
  • Brochospasm
• Gastrointestinal
  • Dyspepsia
  • Nausea/vomiting
• Nervous system
  • Reye's syndrome
• Hypersensitivity reactions
  • Angioedema
  • Urticaria